Dimethyl Sulfoxide
Medchemexpress LLC Dimethyl sulfoxide (GMP like) | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 100mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Apexbio Technology LLC Nexturastat A 1403783-31-2 10mM (in 1mL DMSO)
Nexturastat A (CAS 1403783-31-2) is a selective small-molecule inhibitor of histone deacetylase 6 (HDAC6) It displays potent inhibitory activity against HDAC6 with an IC50 of 5 2 nM While predominantly targeting HDAC6 Nexturastat A also exhibits moderate inhibitory effects on other HDAC isoforms (HDAC1-5 and 7-11) at low micromolar concentrations In cell-based studies including mouse B16 melanoma cell lines Nexturastat A has shown antiproliferative properties and induction of apoptosis Due to its selective HDAC6 inhibition Nexturastat A is utilized in cancer research focusing on epigenetic regulation and therapeutic development
Apexbio Technology LLC Griseofulvin 126-07-8 10mM (in 1mL DMSO)
Griseofulvin is an antifungal antibiotic known to inhibit fungal growth by interfering with microtubule polymerization thereby disrupting mitotic spindle formation and cellular division Through binding to tubulin it stabilizes microtubule structures preventing their normal assembly and leading to impaired fungal cell replication Experimentally Griseofulvin has been frequently utilized to study microtubule dynamics mitotic processes and antifungal mechanisms in research settings involving medically relevant fungi including dermatophytes Reported IC50 values for Griseofulvin range approximately from 5 to 20 M depending on fungal strains and conditions tested serving as a guideline for establishing antifungal assays and investigating fungal response mechanisms in vitro
Apexbio Technology LLC WZ4002 1213269-23-8 10mM (in 1mL DMSO)
WZ4002 (CAS 1213269-23-8) is an irreversible EGFR tyrosine kinase inhibitor that selectively targets mutant epidermal growth factor receptor (EGFR) variants It potently inhibits autophosphorylation of EGFR mutants including T790M L858R/T790M delE746 A750/T790M L858R and delE746 A750 at low nanomolar Ki values Compared to wild-type EGFR mutant EGFR demonstrates greater sensitivity to WZ4002 at lower concentrations limiting off-target toxicity in normal tissues WZ4002 serves as a research tool for studying EGFR-driven tumorigenesis and therapeutic resistance in oncology models
Apexbio Technology LLC Cediranib (AZD217) 288383-20-0 10mM (in 1mL DMSO)
Cediranib (AZD2171 CAS 288383-20-0) is an orally bioavailable small molecule inhibitor targeting the kinase insert domain receptor (KDR VEGFR-2) with potent inhibition observed in recombinant assays (IC50 1 nM) Additionally cediranib suppresses related vascular endothelial growth factor receptors VEGFR-1 (Flt-1 IC50 5 nM) and VEGFR-3 (Flt-4 IC50 3 nM) It also blocks select platelet-derived growth factor receptors notably c-Kit PDGFR PDGFR and CSF-1R at nanomolar to sub-micromolar concentrations indicating multiple-kinase targeting capability Cediranib serves as a valuable research compound for studying tumor angiogenesis and kinase-driven oncogenic pathways
Apexbio Technology LLC Tenofovir Disoproxil Fumarate 202138-50-9 10mM (in 1mL DMSO)
Tenofovir disoproxil fumarate is an antiviral nucleotide analog functioning as a nucleoside reverse transcriptase inhibitor (NRTI) Upon cellular uptake it undergoes enzymatic hydrolysis to form the active metabolite tenofovir subsequently phosphorylated to the diphosphate derivative This phosphorylated metabolite competitively inhibits HIV-1 reverse transcriptase and induces DNA chain termination In vitro studies using MT-2 cells and peripheral blood mononuclear cells (PBMC) have demonstrated suppression of HIV replication with reported EC50 values approximately 0 007 mol/L and 0 005 mol/L respectively This compound is routinely utilized in research investigating HIV replication mechanisms antiretroviral therapies and drug resistance profiles
Apexbio Technology LLC Dynasore 304448-55-3 10mM (in 1mL DMSO)
Dynasore is a non-competitive inhibitor targeting dynamin family GTPases including dynamin1 dynamin2 and Drp1 with an IC50 of approximately 15 M Dynamin GTPases mediate membrane fission processes required for endocytosis and intracellular vesicle trafficking through catalyzing GTP hydrolysis Dynasore inhibits dynamin-mediated endocytic pathways by blocking GTPase activity thus preventing vesicle scission during endocytosis In biological research dynasore is frequently used to investigate dynamin-dependent endocytosis in cellular and neuronal models facilitating studies on synaptic vesicle recycling membrane trafficking and signaling dynamics
Apexbio Technology LLC EHT 1864(Synonyms: EHT-1864, EHT1864, RAC inhibitor EHT1864, Rac GTPase inhibitor EHT 1864), 10mM (in 1mL DMSO), CAS: 754240-09-0.
EHT 1864 (CAS 754240-09-0) is a small-molecule inhibitor targeting Rac family GTPases with strongest affinity and inhibitory activity toward Rac1 It interacts directly with Rac isoforms Rac1 Rac1b Rac2 and Rac3 exhibiting Kd values of approximately 40 nM 50 nM 60 nM and 250 nM respectively By disrupting nucleotide binding EHT 1864 blocks Rac1 activation and prevents the formation of active Rac1/PAK-RBD complexes thus inhibiting downstream cellular functions such as PDGF-stimulated lamellipodia formation and Rac1-mediated cellular transformation This compound serves as a valuable tool in cell biology research for studying Rac-dependent signaling pathways and cellular dynamics
Apexbio Technology LLC LB42708 226929-39-1 10mM (in 1mL DMSO)
LB42708 (CAS 226929-39-1) is a selective small-molecule inhibitor of farnesyltransferase (FTase) belonging to a non-peptidic pyrrole-based class It blocks FTase-mediated farnesylation of H-Ras N-Ras and K-Ras4B demonstrated by low nanomolar IC50 values (0 8 nM 1 2 nM and 2 nM respectively) LB42708 shows minimal inhibitory effect on geranylgeranyltransferase I In vitro studies indicate inhibition of Ras-driven signaling pathways decreasing Ras activation and subsequently suppressing VEGF-stimulated endothelial proliferation and migration Researchers use LB42708 in oncology and inflammation studies exemplified by reduced tumor growth in Ras-mutant HCT116 and wild-type Caco-2 xenograft models
Apexbio Technology LLC Indirubin 479-41-4 10mM (in 1mL DMSO)
Indirubin (CAS 479-41-4) is a small molecule isolated from Danggui Longhui Wan a herbal medicine formulation It exerts anti-inflammatory effects primarily through the inhibition of interferon-gamma (IFN- ) production In vitro studies demonstrated that Indirubin suppresses IFN- secretion in human bone marrow mononuclear cells (HBL-38) and murine splenocytes without affecting cell proliferation In vivo administration of Indirubin reduced ear swelling in a mouse model of 2 4 6-trinitro-1-chlorobenzene (TNCB)-induced delayed-type hypersensitivity concomitant with decreased IFN- levels in lymphocyte cultures Indirubin is under clinical investigation for conditions such as psoriasis and acute promyelocytic leukemia
Apexbio Technology LLC Chlorquinaldol 72-80-0 10mM (in 1mL DMSO)
Chlorquinaldol is a synthetic antimicrobial agent exhibiting antifungal and antibacterial properties commonly utilized in biomedical research for evaluating local antiseptic mechanisms It functions primarily through disrupting microbial membrane integrity and interfering with essential enzymatic pathways ultimately limiting microbial proliferation Chlorquinaldol is frequently employed in vitro for susceptibility testing and characterizing antimicrobial activity against various fungal and bacterial strains In experimental assays its antifungal activity is evaluated through measurement of inhibitory concentrations with reported IC50 values typically ranging between 10-50 g/mL depending on specific microorganism types and assay conditions This compound serves as a reference tool in microbiological studies addressing drug susceptibility resistance evaluation and antiseptic compound benchmarking
Apexbio Technology LLC Sulfamethazine 57-68-1 10mM (in 1mL DMSO)
Sulfamethazine (Sulfadimidine) is a sulfonamide antimicrobial agent that exerts antibacterial activity by competitively inhibiting bacterial dihydropteroate synthase an enzyme crucial for the synthesis of folic acid in bacteria Through this enzyme inhibition sulfamethazine disrupts bacterial folate metabolism impairing bacterial DNA and protein synthesis pathways In biomedical research this compound is commonly employed as an investigative tool for studying bacterial infections particularly in animal models representing respiratory and gastrointestinal infections attributed to susceptible bacterial strains In vitro studies report IC50 values for bacterial dihydropteroate synthase inhibition typically ranging from 5 to 50 M depending on experimental conditions and bacterial species tested Additionally sulfamethazine serves as a reference compound in research examining antimicrobial resistance and pharmacokinetic parameters