Dimethyl Sulfoxide
Apexbio Technology LLC Raltitrexed 112887-68-0 10mM (in 1mL DMSO)
Raltitrexed (CAS 112887-68-0) also known as Tomudex or ZD 1694 is a small-molecule antimetabolite utilized primarily in oncology research As a thymidylate synthase inhibitor raltitrexed disrupts DNA synthesis by impeding nucleotide biosynthesis thereby exerting cytotoxic effects against rapidly dividing tumor cells The compound serves as a tool in cancer studies aimed at elucidating thymidylate synthase s role in tumor cell proliferation and evaluating antitumor therapeutic approaches targeting this enzymatic pathway
Apexbio Technology LLC Bindarit 130641-38-2 10mM (in 1mL DMSO)
Bindarit (CAS 130641-38-2) also known as AF-2838 is a synthetic small-molecule inhibitor targeting the CC chemokines MCP-1 (CCL2) MCP-2 (CCL8) and MCP-3 (CCL7) By suppressing the transcription and production of MCP proteins Bindarit reduces monocyte chemoattraction and inflammation In vitro data indicate that Bindarit inhibits LPS-induced MCP-1 synthesis in monocytes with an IC50 around 172 M and selectively decreases MCP expression without impacting unrelated cytokines such as IL-6 or IL-8 Animal studies demonstrate its potential to reduce inflammatory cell infiltration vascular smooth muscle cell proliferation and neointimal hyperplasia in rodent injury models highlighting its value for inflammation and cardiovascular disease research
Apexbio Technology LLC Chlorquinaldol 72-80-0 10mM (in 1mL DMSO)
Chlorquinaldol is a synthetic antimicrobial agent exhibiting antifungal and antibacterial properties commonly utilized in biomedical research for evaluating local antiseptic mechanisms It functions primarily through disrupting microbial membrane integrity and interfering with essential enzymatic pathways ultimately limiting microbial proliferation Chlorquinaldol is frequently employed in vitro for susceptibility testing and characterizing antimicrobial activity against various fungal and bacterial strains In experimental assays its antifungal activity is evaluated through measurement of inhibitory concentrations with reported IC50 values typically ranging between 10-50 g/mL depending on specific microorganism types and assay conditions This compound serves as a reference tool in microbiological studies addressing drug susceptibility resistance evaluation and antiseptic compound benchmarking
Apexbio Technology LLC Levonorgestrel 797-63-7 10mM (in 1mL DMSO)
Levonorgestrel is a synthetic progesterone analog structurally categorized as a progestin exhibiting agonistic activity primarily through progesterone receptor (PR) binding and also showing interaction with estrogen receptors (ER) Upon receptor binding levonorgestrel modulates transcriptional activity influencing downstream gene expression related to reproductive processes This molecular interaction reduces luteinizing hormone levels inhibits ovulation and induces alterations in uterine lining and cervical mucus thus contributing to contraceptive activity Biomedically levonorgestrel is widely utilized in research for studying progesterone receptor signaling pathways hormonal regulation mechanisms and contraceptive drug development
Apexbio Technology LLC GSK 650394 890842-28-1 10mM (in 1mL DMSO)
GSK 650394 is a small-molecule inhibitor selectively targeting serum- and glucocorticoid-regulated kinase 1 (SGK1) showing inhibition through competitive binding mechanism with an IC50 of approximately 13 nM in fluorescence polarization assays SGK1 functions as an androgen-regulated kinase inhibition of this signaling reduces androgen-driven growth in prostate cancer cell lines Experimental studies demonstrate that GSK 650394 blocks SGK1 and SGK2 kinase activity with IC50 values of 62 nM and 103 nM respectively assessed by scintillation proximity assays Additionally GSK 650394 reduces androgen-induced phosphorylation of SGK substrate Nedd4-2 and suppresses androgen-stimulated proliferation of prostate cancer LNCaP cells (IC50 1 M) suggesting its use in prostate cancer research as a potential therapeutic strategy
Apexbio Technology LLC AZD7545 252017-04-2 10mM (in 1mL DMSO)
AZD7545 (CAS 252017-04-2) is a selective small molecule inhibitor targeting pyruvate dehydrogenase kinase 2 (PDHK2) PDHK2 negatively regulates the pyruvate dehydrogenase (PDH) enzyme complex which converts pyruvate to acetyl-CoA By inhibiting PDHK2 AZD7545 enhances PDH activity In biochemical assays AZD7545 shows potent inhibition of PDHK2 with an IC50 of 6 4 nM whereas it demonstrates somewhat lower potency against PDHK1 (IC50 36 8 nM) In vivo studies using Zucker (fa/fa) rats indicate that AZD7545 administration significantly elevates PDH activity in liver skeletal muscle and heart tissues Thus AZD7545 is proposed as a research tool or therapeutic candidate for metabolic disorders including type 2 diabetes
Apexbio Technology LLC GZD824 1421783-64-3 10mM (in 1mL DMSO)
GZD824 (CAS 1421783-64-3) is an orally bioavailable inhibitor of the Bcr-Abl kinase a fusion protein exhibiting tyrosine kinase activity involved in regulating cell cycle progression and genomic stability GZD824 binds competitively to the ATP-binding site of Abl kinase effectively inhibiting the phosphorylation and activation of both wild-type (WT) and resistant mutant forms (e g T315I E255K G250E Q252H H396P M351T and Y253F) GZD824 demonstrates sub-nanomolar IC50 values and substantially reduces proliferation in Bcr-Abl-expressing Ba/F3 cell models Preclinical studies in mouse xenograft leukemia models show GZD824 suppresses tumor growth highlighting its potential applicability in research into resistance mechanisms and targeted leukemia therapies
Apexbio Technology LLC Staurosporine 62996-74-1 10mM (in 1mL DMSO)
Staurosporine is an alkaloid compound originally isolated from the bacterium Streptomyces staurospores and functions as a broad-spectrum inhibitor of serine/threonine protein kinases It potently inhibits multiple kinases including protein kinase C (PKC) protein kinase A (PKA) epidermal growth factor receptor kinase (EGF-R kinase) calmodulin-dependent protein kinase II (CaMKII) phosphorylase kinase and ribosomal protein S6 kinase Its activity against PKC exhibits an IC50 value of approximately 2 7 nM In biomedical research staurosporine is commonly employed to induce apoptosis in mammalian cancer cell lines and to investigate the roles and signaling pathways of protein kinases
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide 99.5 (GC), plant cell culture tested, 67-68-5, MFCD00002089
Dimethyl sulfoxide 99.5 (GC), plant cell culture tested
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, for molecular biology, Synonym: DMSO
eMolecules n-Butyl sulfoxide | 2168-93-6 | MFCD00002093 | 25g
Oakwood Chemicals | n-Butyl sulfoxide | 25g | 480102057 | 002969 | | 2168-93-6 | MFCD00002093 | 162.290 | C8H18OS
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Apexbio Technology LLC Raltegravir (MK-0518) 518048-05-0 10mM (in 1mL DMSO)
Raltegravir (MK-0518) is an inhibitor targeting HIV-1 integrase an enzyme essential for viral genome integration into host cellular DNA This compound disrupts the integrase-catalyzed strand transfer step during viral replication thereby hindering productive HIV infection In vitro studies demonstrate that Raltegravir inhibits replication of multidrug-resistant strains and isolates utilizing either CCR5 or CXCR4 coreceptors Its reported IC50 values typically range within the low nanomolar concentration levels Raltegravir is widely employed as a tool molecule in antiviral mechanism research drug resistance assays and preclinical HIV therapy-focused drug screening studies
Apexbio Technology LLC Skepinone-L 1221485-83-1 10mM (in 1mL DMSO)
Skepinone-L (CAS 1221485-83-1) is a selective ATP-competitive inhibitor of p38 mitogen-activated protein kinase (MAPK) This kinase family transduces signals from diverse cellular stressors regulating processes like apoptosis and differentiation Skepinone-L potently inhibits p38 MAPK activity with an IC50 of approximately 5 nM In vitro it dose-dependently reduces phosphorylation of heat shock protein 27 (HSP27) a downstream marker of p38 MAPK in HeLa cells Additionally the compound suppresses key cytokine release (e g TNF- IL-1 IL-10) in human peripheral blood mononuclear cells Oral administration in mice effectively reduced TNF- production illustrating potential applications in inflammation and signaling pathway research
Apexbio Technology LLC LDN193189 Hydrochloride 1062368-62-0 10mM (in 1mL DMSO)
LDN193189 Hydrochloride is a selective pharmacological inhibitor targeting BMP type I receptor kinases specifically activin receptor-like kinase 2 (ALK2) and ALK3 The compound acts by blocking receptor-mediated activation of Smad-dependent signaling pathways (Smad1/5/8 phosphorylation) as well as mitigating associated non-Smad signaling including phosphorylation of Akt and p38 Commonly utilized in biomedical research involving cellular differentiation epithelial barrier integrity and heterotopic ossification LDN193189 has shown the capacity to modulate BMP-induced phenotypic changes in various cell lines such as C2C12 myoblasts and bronchial epithelial cells and to influence related in vivo processes
Apexbio Technology LLC SU5416 204005-46-9 10mM (in 1mL DMSO)
SU5416 (CAS 204005-46-9) also known as Semaxanib is a small molecule inhibitor designed to block vascular endothelial growth factor receptor (VEGFR2) particularly targeting Flk-1/KDR receptor tyrosine kinase signaling SU5416 effectively inhibits VEGF-induced phosphorylation of Flk-1 thereby interfering with endothelial cell proliferation angiogenesis and subsequent tumor vascularization Preclinical studies demonstrated suppression of tumor growth accompanied by angiogenesis inhibition Additionally SU5416 acts as an agonist of the aryl hydrocarbon receptor (AHR) modulating immune responses via induction of indoleamine 2 3-dioxygenase (IDO) and regulatory T cell differentiation These properties suggest potential utility not only in cancer research but also in investigating autoimmune conditions and transplant tolerance